PhD, MSc Projects (ongoing and future)

Areas of scientific activity:

Modeling of structure and dynamics of membrane proteins and their complexes with ligands and other proteins. Drug design. Development of new methods of coarse-grain dynamics. Studies of interactions of proteins with graphene, carbon nanotubes and other electrode materials for biosensor applications.

Exemplary titles of expected Master/Doctoral theses:

  • Modeling of action of agonist/antagonist sensor and molecular switches of formyl / opioid / cannabinoid / chemokine / etc. receptors from GPCR family using theoretical methods.
  • Studies of formation and dynamics of oligomers of membrane proteins.
  • Design of drugs preventing aggregation of beta-amyloid / activating or deactivating GPCRs / etc.
  • Interactions of modified graphene or other electrode nanomaterial with proteins.

Tematyki badawcze:

Modelowanie struktury i dynamiki białek błonowych oraz ich kompleksów z ligandami oraz z innymi białkami. Projektowanie leków. Rozwój nowych metod symulacji gruboziarnistych. Badanie oddziaływań białek z grafenem, nanorurkami i innymi materiałami elektrodowymi do zastosowania w bioczujnikach.

Przykładowe przewidywane tematy prac magisterskich/doktorskich:

  • Modelowanie działania sensora agonista/antagonista oraz przełączników molekularnych receptorów formylowych / opioidowych / kanabinoidowych / chemokinowych i innych z rodziny GPCR metodami teoretycznymi.
  • Badanie powstawania i dynamiki oligomerów białek błonowych.
  • Projektowanie leków przeciwdziałających agregacji beta-amyloidu / aktywujących lub deaktywujących receptory GPCR i inne.
  • Oddziaływanie modyfikowanego grafenu lub innego nanomateriału elektrody z białkami.

The applicants interested in working in our group are welcomed to contact us

Minimal requirements for candidates:

  • Practical knowledge of at least one protein visualizing/modeling program (e.g. YASARA, VMD, PyMol, MolMol, SPDBviewer)
  • Knowledge of types of protein structures
  • Practical usage of biological web servers (e.g. UniProt, ExPASy, BLAST, Protein Data Bank)
  • Basic programming skills (e.g. Python, Perl, C, C++, Fortran)
  • Good knowledge of English

  • April 2019.
    Our latest review on "Molecular switches in GPCRs".

  • March 2019.
    The ERNEST project (COST CA18133) has started.
    ERNEST = European Research Network on Signal Transduction
    The main scientific objective of the Action is to develop a common, comprehensive and holistic map of signal transduction that will advance development of pathway-specific chemical modulators. This unique and innovative goal will be realised by linking of a diverse group of researchers in the field through the networking activities funded by COST.
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