Scientific interests
- Drug design
- Modeling of structure and dynamics of membrane proteins
- Action of molecular switches on activation pathway of GPCRs, agonist/antagonist sensors
- Development of new methods for coarse-grain dynamics
- Oligomerization processes of proteins and peptides
- Interactions of proteins with graphene, carbon nanotubes and other electrode materials
- Simulated mechanical unfolding of proteins
Graphics created by Shuguang Yuan
Membrane receptor with a membrane and water in a periodic box.
Major investigated proteins
- G-protein-coupled receptors - GPCRs (rhodopsin, adrenergic / opioid / cannabinoid / chemokine / … receptors)
- Bacteriorhodopsin, halorhodopsin
- Membrane proteases including the γ-secretase complex (Alzheimer disease)
- Glucose oxidase (for biosensors)
THE LATEST NEWS
- June 2021.GPCRsignalOur new service GPCRsignal was recently published in NAR 2021, W1.
- April 2019.Our latest review on "Molecular switches in GPCRs".
CONFERENCES
- The 2nd ERNEST conference:
"New Perspectives in Signal Transduction: GPCRs and Beyond",
Boğaziçi University in Istanbul,
TURKEY on March 28-30, 2020.
- The 1st ERNEST conference:
"GPCR Pharmacology:
Activation, Signalling and Drug Design",
October 28-30, 2019,
Queen's University Belfast, Northern Ireland, UK
